first down (and ten to go)

Meaning 1
A team makes a first down if it moves ten yards towards the opponents goal post. The team has four chances or downs to do this.
Sentence 1
The fullback made it look easy to get first downs for his team.
Meaning 2
to have accomplished an objective on the way to a goal
Sentence 2
We have a first down . Everyone work hard and maybe we'll get the contract. The surgeon said, " Frst down and ten to go . We got the tumor. Now we need some chemotherapy."